SYSTEMATIC LITERATURE REVIEW OF ECONOMIC EVALUATIONS AND HEALTHCARE RESOURCE UTILISATION STUDIES IN THE TREATMENT OF CLOSTRIDIUM DIFFICILE INFECTION
Author(s)
Ahir HB1, Marcella S2, Jiang Y3, Mayes A1, Burnett H4, Rajpura J4
1MSD Ltd, Hoddesdon, UK, 2Merck & Co., Inc., Kenilworth, NJ, USA, 3Merck Sharp & Dohme Ltd., Hoddesdon, Hertfordshire, UK, 4Mapi, Toronto, ON, Canada
OBJECTIVES: The aim of this systematic literature review (SLR) was to identify and summarise all available evidence for Clostridium difficile infection (CDI), with regards to: health economic models that evaluate and compare alternative treatment strategies and studies that evaluate the economic burden of CDI and its treatment, in terms of healthcare resource utilisation (HCRU). METHODS: A systematic search was conducted in December 2016; focused on capturing existing economic models and HCRU studies. Databases searched included: MEDLINE®, Embase®, EconLit, National Health Service Economic Evaluation Database (NHS-EED), Database of Abstracts of Reviews of Effects, and Health Technology Assessments (HTA). A comprehensive hand-search of conference abstracts, HTA body websites and the Tufts CEA registry were undertaken. Screening of abstracts and full-texts were performed by two independent researchers with consensus being facilitated through a third-party. Data extraction was carried out by a single researcher and validated by a second researcher. RESULTS: The search identified 4,995 records. Overall, 95 full text articles and 6 conference abstracts were included; of which CONCLUSIONS: The results of this SLR provides a comprehensive summary of all published evidence available for treatment of CDI and can be used to support the development of and inputs required for global adaptations of health economic models. There is a lack of HCRU evidence for recurrent CDI populations, which identifies an area of possible future research.
Conference/Value in Health Info
2017-11, ISPOR Europe 2017, Glasgow, Scotland
Value in Health, Vol. 20, No. 9 (October 2017)
Code
PIN68
Topic
Economic Evaluation
Topic Subcategory
Cost/Cost of Illness/Resource Use Studies
Disease
Infectious Disease (non-vaccine)