OBJECTIVES:

Hypertension is first rank of chronic disease found in Indonesian primary health care. Cardiovascular disease could happen from uncontrolled of blood pressure as existing of drug related problems. This study was to investigate the prevalence and nature of drug related problems in outpatients with hypertension and reveal any association between DRPs and the therapeutic outcomes in these patients

METHODS:

This was a cross sectional study. A total of 214 hypertension patients who fulfilled the inclusion criteria were recruited through outpatient clinic from seven primary health care in Yogyakarta province, Indonesia that collected during year 2016. The patient’s blood pressure was follow up for one to three month. During this period of therapy the patients could come to the clinic several times as the medication serve for around two to four week from the clinic. Patients’ data were assessed to identify DRPs using an evidence-based approach.

RESULTS:

This study found about half of the participants (54 %) had uncontrolled blood pressure. A Total of 323 DRPs were identified. The average number of DRPs was 1.5. per patient and most of the patients (90%) have at least one DRPs. The main DRPs affecting uncontrolled therapeutic outcome included sub optimal doses of medication prescriber. nonadherence to the medication, drug-drug interaction. Significant associations were found between poor blood pressure control and the existing of DRPs (p=0.000).

CONCLUSIONS:

The number of DRPs among patients with hypertension was relatively high. These DRPs were associated with poor therapeutic outcome of hypertension patients. The iimprovement of clinical pharmacy services for all patients with hypertension is strongly recommended.

apeutic outcome included sub optimal doses of medication prescriber. nonadherence to the medication, drug-drug interaction. Significant associations were found between poor blood pressure control and the existing of DRPs (p=0.000).