FACTORS ASSOCIATED WITH QUALITY OF LIFE(QOL) IN PERIPHERAL ARTERIAL DISEASE(PAD) PATIENTS IN KOREA- RESULTS FROM PAD OUTCOMES RESEARCH(OR)
Author(s)
Choi D1, Rha S2, Choi S3, Kim HJ4, Kim Y4
1Yonsei University Health System, Seoul, Korea, Republic of (South), 2Korea University Guro Hospital, Seoul, Korea, Republic of (South), 3Samsung Medical Center, Seoul, Korea, Republic of (South), 4Pfizer Pharmaceuticals Korea Ltd., Seoul, Korea, Republic of (South)
OBJECTIVES: Even though PAD is known to have significant effect on QoL, due to its asymptomatic nature, it is often underdiagnosed and undertreated. Therefore, in this study, we investigated factors associated with patients’ change of QoL(ΔQoL) in Korea. METHODS: Data in this analysis was from PAD OR, which was a prospective, observational study conducted from June 2013~August 2014 in 23 participating tertiary-hospitals. Patients with age≥20years, ankle-brachial index(ABI)≤0.9, and lower-extremity artery stenosis≥50% on CT-angiography or peak-systolic-velocity-ratio(PSVR)≥2.0 on duplex sonography were included. Clinical characteristics were collected through medical chart review, and QoL was assessed via patient survey using EQ-5D and EQ-VAS measures. Data were collected at the time of study enrollment and at 6-month follow-up(FU). Multiple linear regression analysis was conducted to assess factors associated with ΔQoL after 6-month. RESULTS: Total of 1,260 patients(mean age 69.76±9.94, male 77.0%) were included in the analysis. Patients’ mean EQ-5D index scores significantly increased by 0.04±0.20(p<0.0001) after 6 months(baseline;0.64±0.24, 6-month FU;0.68±0.20). As a result of multivariable analysis, factors associated with ΔQoL was change of Fontaine stage where ‘Improvement of Fontaine stage’ compared to ‘No change’(B=0.06646, p<0.0001) had positive effect on ΔQoL and ‘Deterioration of Fontaine stage’ compared to ‘No change’(B=-0.03902, p=0.0246) had negative effect on ΔQoL. Underlying conditions such as diabetes(B=0.02299, p=0.0469) had a positive effect, while cardiovascular comorbidities(B=-0.03132, p=0.0101) had a negative effect. Others such as treatment with pharmacotherapy(B=0.05257, p=0.0356) and patients’ smoking status of no smoking for the past 6 months compared to current smoking(B=-0.03254, p=0.0399), had a positive effect on ΔQoL. CONCLUSIONS: Since PAD is often diagnosed after symptom deterioration, patients’ QoL is more likely to be have been impacted even before the disease diagnosis. Therefore, more attention to the disease for earlier diagnosis and provision of timely pharmacotherapy is critical in management of patients’ QoL.
Conference/Value in Health Info
2017-11, ISPOR Europe 2017, Glasgow, Scotland
Value in Health, Vol. 20, No. 9 (October 2017)
Code
PCV128
Topic
Patient-Centered Research
Topic Subcategory
Patient-reported Outcomes & Quality of Life Outcomes
Disease
Cardiovascular Disorders