OBJECTIVES: To evaluate the anti-asthmatic potential of Artemisia pallens methanol extract (APME) in ovalbumin (OVA)-induced airway hyperresponsiveness (AHR) in laboratory rats. METHODS: The methanolic extract of aerial parts of Artemisia pallens (APME) was prepared. The AHR was induced in the male Wistar rats by intraperitoneal (i.p.) injection of OVA. Rats received treatment of either APME (100, 200, and 400 mg/kg, p.o.) or vehicle from next 28 day. Various behavioral, biochemical, molecular and histopathological parameter were assessed. RESULTS: Treatment with APME (200 and 400 mg/kg) showed the significant restoration (p <