OBJECTIVE: When Stroke accounts for 6·4% of all deaths and thus ranks 3rd after heart disease &gastrointestinal with a crude prevalence rate of 963/100 000 inhabitants. The clinical characteristics of Egyptian stroke patients are generally similar to those in other populations. Exceptions may include the higher prevalence of vascular risk factors and a younger mean age of stroke patients (4, 18–20). Due to those facts stroke &its complications may be one of the major economic challenges facing Egyptian health sector. The objective of this study is to evaluate Economic evaluation for establishing stroke unit followed by early supported discharge the outcome was determined as survival with minor disability . METHOD: Integration between A systematic literature review &Descriptive analysis of Data from patients aged (18 -60 years ) for the last 3 years including direct and indirect medical costs for conventional treatment including ( cost of treatment, complications including physical therapy , hospitalization ,outpatients costs ,rehabilitation ). The total (n) of patients enrolled in the national database = 3212. One way sensitivity analysis was conducted. Level of statistical significance was defined at (p. <0.05). RESULT: Mean direct medical cost for (, neurological complications including Cerebral Edema, DVT, PE, Hemorrhagic transformation,) increasing ratio was around 3.5% at the last 3 years. Cardiac Complications were second items for cost with increasing rates2 .5, respiratory Complications ranking 3^rd with 1.5 rate at last 3 years. Hospitalization ratio increased with 5.7 % for the last 3 years. CONCLUSION: Establishing stroke unit followed by early supported discharge might be cost saving due to it is significant impact of minimizing economic consequences of