DISEASE BURDEN OF FRACTURES IN PATIENTS WITH OSTEOPOROSIS IN JAPAN
Author(s)
Fujiwara S1, Umareddy I2, Jaffe D3, Teoh C2, Taguchi Y4
1Hiroshima Atomic Bomb Casualty Council, Hiroshima, Japan, 2Kantar Health, Singapore, Singapore, 3Kantar Health, Tel Aviv, Israel, 4Amgen Astellas BioPharma K.K., Tokyo, Japan
OBJECTIVES: Osteoporosis remains undertreated in Japan, and bone fractures are the most frequent complications imposing heavy burden on individuals and the community. This research investigates the disease burden of fractures in osteoporosis patients (≥50 years old) in Japan with respect to health status, work productivity and activity impairment (WPAI), and healthcare resource utilization. METHODS: This study uses the National Health and Wellness Survey (NHWS) 2012–2014 database in Japan with participants’ demographics, health history and health outcomes assessed. Respondents who were aged ≥50 years old and indicated a physician diagnosis of osteoporosis were included (N=1107). Participants with/without prior fractures after age of 50 were compared with respect to health status (assessed via the mental [MCS] and physical component summary [PCS] scores from the Short Form-36v2), WPAI (assessed via the WPAI-GH instrument) and self-reported healthcare resource utilization in the past 6 months. A secondary analysis was conducted to compare between respondents with ≥2 bone fractures (N=172) and those with 1 bone fracture (N=242) to assess the association between estimated burden and incremental fractures. Comparisons were made using one-way ANOVAs with a significance level of p<0.05. RESULTS: Total 414 osteoporosis patients reported prior fractures (female: 92%; mean age: 66.6). Comparing to those without prior fractures, respondents with prior fractures reported significant lower PCS (46.1 vs. 48.7), MCS (47.2 vs. 49.0), health utilities (0.69 vs. 0.72), and significant greater productivity loss due to presenteeism (26.6% vs. 18.8%), activity impairment (34.6% vs. 28.9%), physician visits (13.4 vs. 10.8) and hospitalizations (3.0 vs. 1.1). Similar results were observed for respondents with ≥2 bone fractures compared with those with 1 bone fracture. CONCLUSIONS: Fractures in osteoporosis patients were associated with poorer health status, greater work productivity loss due to presenteeism and greater healthcare resource utilization. A significant greater burden with incremental fractures was also identified.
Conference/Value in Health Info
2017-11, ISPOR Europe 2017, Glasgow, Scotland
Value in Health, Vol. 20, No. 9 (October 2017)
Code
PHS55
Topic
Economic Evaluation
Topic Subcategory
Cost/Cost of Illness/Resource Use Studies
Disease
Musculoskeletal Disorders