OBJECTIVES:The immune system responding to allergens may affect the prognosis of prostate cancer. Therefore, comorbid allergic conditions among prostate cancer patients may influence cancer screening practice, treatment choice, and patient’s quality of life and survival. This study examined the long-term trends in prevalence and factors associated with allergic conditions among prostate cancer patients.

METHODS: A serial, cross-sectional study was conducted using the National Health Interview Survey data from 2007 through 2016. Two self-reported allergic conditions (asthma or hay fever) and prostate cancer diagnosis were identified from survey questions asking if a participant had hay fever last year and had asthma and prostate cancer ever. Simple linear regression models were applied to test annual prevalence trend in allergic conditions among prostate cancer patients. Multivariable logistic regression model was used to identify factors associated with allergic conditions among prostate cancer patients. Statistical significance was set at P<0.05 and all results were weighted to represent national estimates.

RESULTS: A total of 3,311 prostate cancer patients (average weighted n=0.24 million/year) were identified over the 10-year period. Annually, about 16% of prostate cancer patients had asthma or hay fever from 2007 to 2016. The annual prevalence of allergic conditions trend was stable from 2007 to 2016 (trend P= CONCLUSIONS: This study found high prevalence of allergic conditions among U.S. prostate cancer patients. In 2007-2016, the overall trend in allergic conditions prevalence among prostate cancer patients remained stable. Understanding prevalence of allergic conditions and associated factors helps practitioners better assess disease burden and improve clinical decision making in treatment for prostate cancer patients with comorbidities. Future research should assess treatment patterns and how treatments affect outcomes for patients with prostate cancer and comorbid allergic conditions.