QUALITY OF LIFE AND FUNCTIONAL IMPAIRMENT RESULTS- A PROSPECTIVE REAL-WORLD DYSKINESIA SCREENING STUDY AND REGISTRY IN PATIENTS TAKING ANTIPSYCHOTIC AGENTS
Author(s)
Caroff SM1, Cutler A2, Lenderking WR3, Yeomans K4, Shalhoub H5, Ford AM6, Yonan C7
1Corporal Michael J. Crescenz Veterans Affairs Medical Center and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA, 2Meridien Research, Tampa, FL, USA, 3Evidera, Bethesda, MD, USA, 4Evidera, Montreal, QC, Canada, 5Evidera, Waltham, MA, USA, 6PPD, Morrisville, NC, USA, 7Neurocrine Biosciences, Inc., San Diego, CA, USA
OBJECTIVES: To investigate the presence and burden of possible tardive dyskinesia (TD) in a real-world population of patients taking antipsychotics (RE-KINECT:NCT03062033). METHODS: RESULTS: Of 236 patients with available data, 28% had clinician-confirmed possible TD (Cohort 2). Baseline characteristics were (Cohort 1, Cohort 2): mean age[SD] (47.2[14.1], 56.6[12.0]); female (61%, 61%); full-time employment (22%, 13%); mean lifetime exposure to antipsychotic(s), years (7.2[8.2], 15.1[14.0]); schizophrenia/schizoaffective disorder (21%, 42%); bipolar disorder (54%, 49%); major depressive disorder (37%, 34%); anxiety disorder (34%, 54%). In all but one domain, a higher percentage in Cohort 2 reported at least “some problems” on the EQ-5D-5L (Cohort 1, Cohort 2; %): mobility (28, 48), self-care (14, 30), usual activities (45, 52), pain/discomfort (50, 65), and anxiety/depression (76, 73). Cohort 2 also had higher mean scores (SD) in all SDS domains (more impairment) (Cohort 1, Cohort 2): work/school work (4.2[3.6], 4.3[3.2]), social life (3.5[3.2], 4.4[3.3]), family life/home responsibilities (3.7[3.2], 4.2[3.0]). CONCLUSIONS: Current results from this novel patient registry suggest that the abnormal involuntary movements of TD contribute to functional impairment and may be associated with other variables that negatively affect QoL. Final results will be presented at the meeting.
Conference/Value in Health Info
2018-05, ISPOR 2018, Baltimore, MD, USA
Value in Health, Vol. 21, S1 (May 2018)
Code
PMH48
Topic
Patient-Centered Research
Topic Subcategory
Patient-reported Outcomes & Quality of Life Outcomes
Disease
Mental Health