IMPACT OF HEMOPHILIC ARTHROPATHY ON THE CONSUMPTION OF ANTI-HEMOPHILIC FACTORS DUE TO SPONTANEOUS AND TRAUMATIC BLEEDING EVENTS IN SEVERE HEMOPHILIA PATIENTS WITHOUT THE PRESENCE OF INHIBITORS IN COLOMBIA
Author(s)
Agudelo C1, Canon O2, Lamos C3
1Grupo Sanitas, Bogota, Colombia, 2GBT, Bogota, Colombia, 3Universidad del Bosque, Bogota, Colombia
OBJECTIVES : To calculate differences in the consumption of anti-hemophilic factors in patients with hemophilic arthropathy. METHODS A retrospective study was conducted from the electronic records of the bleeding events (926 events) that were attended in 12 cities of Colombia, between January 2014 and December 2015. RESULTS: It was identified that patients with arthropathy have a greater consumption of factors in the prophylaxis, 79 vs 64 IU / Kg / WK, for a difference of 15 IU / KG / Wk (CI95 11; 18 p <0.005, a greater number of applications per event, 3.1 vs 1.8, with a significant difference of 1.3 (IC95 1.0, 3.1 p <0.005), a higher dose per bleeding event of 96 VS 56 IU / KG with a significant difference of 43 IU / kg (CI 95 53, 96 p <0.005), for a greater total factor consumption in patients with hemophilic arthropathy (97 versus 54 IU / kg / week) with a statistically significant difference of 44 IU / kg / week (CI 95 53, 97 P <0.005). CONCLUSIONS: One of the main objectives of prophylaxis in hemophilia is to avoid the development of arthropathy and the progression of it. The presence of arthropathy increases factor consumption both in the prophylaxis of severe hemophilia patients and in consumption during bleeding events. More studies are required to quantify the saving of resources that can be achieved in the Colombian population with the use and adequate initiation of prophylaxis, in companion with multidisciplinary management to avoid the complications of severe hemophilia such as arthropathy.
Conference/Value in Health Info
2018-05, ISPOR 2018, Baltimore, MD, USA
Value in Health, Vol. 21, S1 (May 2018)
Code
PSY59
Topic
Economic Evaluation
Topic Subcategory
Cost/Cost of Illness/Resource Use Studies
Disease
Systemic Disorders/Conditions