OBJECTIVES: The aim of this study was to assess the prevalence of DRP's and associated factors among medical ward patients in three different tertiary care teaching hospital in Punjab, India. This study shows the evaluation of current prescribing pattern to identify different adverse drug reactions, specific drug –drug, drug -food interactions and medication errors. METHODS: The prospective observational study was conducted at Department of Medicine in three different hospital setting in the Moga, District of Punjab, India. Based on the inclusion and exclusion criteria the patient’s after signing the Informed Consent Form data was collected and analyzed using software SPSS version 24. The population size of the study was found to be = 1613254 as per census (2011). RESULTS: A total of 1230 cases were followed and reviewed during the study period. Of the cases reviewed, 353 (78.27 %) DRP's were identified from 451 patients. Out of 451 patients 256 (56.76%) were male and 195 (43.23%) were female. it was found that drug related problems was identified in 451 patients. In which drug interactions was maximum 252 (55.88 %) followed by Adverse reactions 106 (23.50 %). Drug interactions were maximum 252 (55.88 %) followed by adverse reactions 106 (23.50 %). The study reveals that 66 (62.26 % of) ADR’s were from non-allergic whereas 40 (37.74 %) of ADR’s belongs to allergic class as mentioned in table 3. Potential drug-drug interactions were detected in 252 (55.87 %) patients out of the 451. CONCLUSIONS: The present study indicated that DRPs are common among medical ward patients. Noncompliance and unnecessary drug therapy were the top and the least prevalent DRPs respectively. Furthermore, additional steps should be taken to determine the cause of the patient’s symptoms and whether they can be attributed to the use of a drug.