WORKING TITLE- CONTRAINDICATIONS FOR HCV THERAPY IN US PATIENTS WITH UNTREATED CHRONIC HEPATITIS C (CHC)

Author(s)

Le TK1, Kalsekar A2, Yuan Y3, Macaulay D4, Sorg RA4, Behrer CR4, Wei J4, Wu EQ5
1Bristol-Myers Squibb, Hopewell, NJ, USA, 2Bristol-Myers Squibb, Princeton, NJ, USA, 3Bristol-Myers Squibb, Plainsboro, NJ, USA, 4Analysis Group, Inc., New York, NY, USA, 5Analysis Group, Inc., Boston, MA, USA

OBJECTIVES: Describe the prevalence of contraindications to chronic hepatitis C (CHC) treatment among CHC patients not receiving CHC treatment (direct-acting antiviral [DAA] protease inhibitors, peg-interferon alpha, or ribavirin).  METHODS: Adult patients with ≥2 CHC diagnoses (ICD-9-CM codes 070.44, 070.54, 070.70, 070.71) and no DAA fills at any time in their claims history were selected from a de-identified US-based claims database (2010-2012); the first CHC diagnosis after 5/13/2011 was defined as the index date. Patients with CHC treatment 6-months before or 12 months after the index date were excluded. All patients were required to have continuous eligibility and no claims for hepatitis B during the 6-months before (baseline) and 12-months after their index dates. Contraindications (based on a World Health Organization hepatitis C guide) during the baseline period were identified based on ICD-9 codes and described for the overall cohort as well as stratified by age (18-39; 40-49; 50-59; 60-69; 70-79; 80+).  RESULTS: There were

Conference/Value in Health Info

2014-05, ISPOR 2014, Palais des Congres de Montreal

Value in Health, Vol. 17, No. 3 (May 2014)

Code

PGI3

Topic

Epidemiology & Public Health

Disease

Gastrointestinal Disorders

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