OBJECTIVES: Diuretics are drugs of first choice in the treatment of hypertension. The aim of this study was to analyze the consumption of diuretics in Serbia in the period from 2008 to 2012 year. METHODS: The data about the use of drugs were taken from the Agency for Drugs and Medical Devices of the Serbia. RESULTS: The use of diuretics during the observed period in Serbia is quite small and it ranged from 5 to 6% of the total consumption of all drugs from the C group. Furosemide was the most frequently used diuretic from 2008-2010. In the observed period consumption of  furosemide ranged about 61 % of the total consumption of all diuretics. On the second place in consupmtion during  first three years of the study was indapamide. Indapamid records decline in consumption in next two years. In 2011. and 2012. hydrochlorothiazide takes second place in consumption and marks a possitive trend. In 2012. it ranged 7.92 DDD/1000 inh/day. Spironolactone takes the fourth position in the first three years. During the 2011. and  2012.  consumption of spironolactone has increased and took the third position in consumption. Consumption of all other diuretics was small. CONCLUSIONS: In Serbia, in the observed period, consumption of diuterics were uneven. It is two to three times lower in comparison with the consumption of diuretics in Norway and Finland. This research was supported by Provincial Secretariat for Science and Technological Development, Autonomous Province of Vojvodina project No 114-451-2458/2011 and by Ministry of Science, Republic of Serbia, project no 41012.