OBJECTIVES: the costs of treatment of patients with pulmonary embolism (PE), which has developed after large surgery and includes the cost of hospital stay, treatment, the cost of medicines, non-drug technologies and rehabilitation. In most studies, cost estimation is performed using a survey of experts and modeling. The objectives of the study were to conduct a cost analysis of patients with PE, which has showed after the operations in "real" practice. METHODS: A retrospective analysis. When analyzing the costs only direct costs were calculated. Total costs were counted by adding costs of medicines, transaction costs, costs of laboratory and instrumental methods of research, medical services, medical staff, costs of hospital stay. RESULTS: