Introduction: The presence of mental disorders at workplace has been related with absenteeism and decreasing in work performance and in productivity. There are some effective interventions available that can be implemented to reduce the socio economic impact of mental disorders like anxiety and depression at the workplace. OBJECTIVES: To identify the evidence-based interventions available to prevent and to treat anxiety and depression at the workplace and to explore in what extent these interventions have impact on reducing the socio economic effects of mental disorders. METHODS: A search based on depression, anxiety, interventions, prevention, workplace, absenteeism, presenteeism, indirect costs was built in Medline database. Studies were included if they described the intervention and method and their effects on absenteism, presenteeism and costs at workplace. RESULTS: Five main interventions were identified: workplace screening for anxiety and depression disorders and care management: interventions are usually delivered throughout cognitive behavioral therapy (CBT), offered by external psychological service providers; CBT through web-based program: it is offered a web-based program to selected employees. Benefits come out of tackling the disorder and increasing productivity levels due to the reduction of presenteeism; interventions promoting well-being in the workplace: it includes flexible time schedules, career growth opportunities and mental health risk factors recognition training program for managers; financial education: workshop for selected employees to advise them on how to better manage their debts, reducing financial burden and consequently, reducing mental health problems; antidepressant drugs for anxiety and depression: these medicines have a positive impact on the work performance and on the decrease of absenteeism rate. CONCLUSIONS: The studies selected demonstrated a clear benefit of five interventions for depression and anxiety at workplace: improvement in employees´ performance, in quality of life, reduction of health services costs, decrease in absenteeism rate, in accidents, in sick leave benefits and in early retirement.