RELATIVE INFLUENCE OF FACTORS DETERMINING A WOMAN'S PREFERENCE FOR TREATMENT OPTIONS IN OVARIAN CANCER- A DISCRETE CHOICE EXPERIMENT
Author(s)
Havrilesky LJ1, Secord AA1, Ehrisman J1, Berchuck A1, Valea FA1, Lee PS1, Cella D2, Weinfurt K3, Abernethy AP3, Reed SD3
1Duke University, Durham, NC, USA, 2Northwestern University, Chicago, IL, USA, 3Duke Clinical Research Institute and Duke Cancer Institute, Durham, NC, USA
OBJECTIVES: To examine relative preferences for symptoms, treatment-related side-effects and progression-free survival (PFS) in women with ovarian cancer using a discrete choice experiment (DCE). METHODS: A pilot study was conducted of women with advanced or recurrent ovarian cancer. In the DCE, participants were asked to choose between two treatment scenarios, modeled on characteristics of standard intravenous (IV) and intraperitoneal/intravenous (IP/IV) treatments for newly diagnosed ovarian cancer. Each scenario included 7 attributes with 2-3 levels each: mode of administration (IV versus IP/IV); visit frequency (one per week, two per 3 weeks, one per 3 weeks); treatment-related abdominal symptoms, neuropathy, fatigue, nausea, and vomiting; and PFS (15, 18, 21 and 24 months). We used a balanced overlap design with 10 versions of the survey. Each participant evaluated 12 random choice and one fixed-choice scenario. Mixed logit regression modeled participant’s choices as a function of attribute levels. RESULTS:
Conference/Value in Health Info
2014-05, ISPOR 2014, Palais des Congres de Montreal
Value in Health, Vol. 17, No. 3 (May 2014)
Code
PCN144
Topic
Patient-Centered Research
Topic Subcategory
Stated Preference & Patient Satisfaction
Disease
Oncology