OBJECTIVES: Spontaneous reporting of adverse drug events (ADEs) by pharmacists helps ensure safe medication use; an important aspect of pharmaceutical care. This systematic review summarizes published survey articles regarding determinants of ADE reporting by pharmacists METHODS: A literature search was conducted to identify original survey articles regarding pharmacists’ knowledge, attitudes and demographic factors associated with frequency of ADE reporting. Search engines used included PubMed, CINHAL and Web of Science.For each survey article, the following data were extracted: pharmacists working setting, sample size, survey delivery, response rate, reporting rate, demographic factors, knowledge and attitudes associated with reporting RESULTS: Only 32 of the 820 articles identified met the study requirements. The number of respondents in the studies included in this review ranged from 20 to 643. Response rate ranged from 26.4% to 100%. Self – administered questionnaires were used in 47% (15/32) and 41% (13/32) surveyed both hospital and community pharmacists. A study of Canadian pharmacists found that 65% had reported an ADE, followed by 59% and 32% of pharmacists in the UK and the US respectively. Pharmacists were found to have favorable attitude toward reporting (7 studies).Years of work experience as pharmacist was associated with significantly increased ADE reporting in 2 studies. Pharmacists in hospital settings reported significantly more ADEs than pharmacists in community/retail settings (4 studies).Lack of knowledge of pharmacovigilance concepts, systems and/or the ADE reporting process were significant barriers to reporting among 72%; uncertainty that a specific drug is responsible for a particular ADE in 38%;  and lack of time in 34% of studies. The factor most frequently recommended to improve reporting was special training/education programs related to pharmacovigilance concepts and ADE reporting (16/32). CONCLUSIONS: To improve reporting of ADE by pharmacist, educational interventions to address gaps in knowledge and attitudes could be implemented within pharmacy curriculum or as part of continuing education.