OBJECTIVES: To examine factors associated with chronic obstructive pulmonary disease (COPD)-related inpatient readmission among managed care patients in the US.  METHODS: This retrospective administrative claims database analysis included patients with COPD (≥1 inpatient or emergency room claim or ≥2 outpatient claims with a diagnosis of COPD [ICD-9-CM codes 491.xx, 492.xx, 494.xx, or 496.xx]), aged ≥40 years with health plan enrollment in 2011. From this cohort, patients with a COPD-related hospitalization (hospitalization with a primary diagnosis of COPD) and continuous enrollment for ≥30 (30-day cohort) or ≥90 (90-day cohort) days post-discharge were selected for further analysis. Percentages of patients with a COPD-related inpatient readmission in the 30 and 90 day periods post-discharge were reported. Logistic regression models assessed clinical (i.e., length of stay [LOS] for the initial hospitalization; COPD-related medications received [e.g. long-acting bronchodilators (LABDs)] and COPD-related pulmonologist visits post-initial hospitalization; and comorbidity burden, being newly diagnosed with COPD, and COPD complexity pre-hospitalization) and demographic factors associated with 30- and 90-day readmission. RESULTS: