OBJECTIVES: The first aim of this study is to collect individual-level patient data for a retrospective cohort study examining the demographics of patients diagnosed with Alpha Human Herpes Viruses (α-HHV) infection, and patients with low Thyroid levels (Thyroid disorder) over a 6-year period. The second aim is to test statistically that low Thyroid levels are related to higher prevalence of α-HHV. METHODS: The data will be obtained from Peninsula Regional Medical Center located in Salisbury, Maryland. The adjusted medical claims will be identified using ICD-9-CM codes for the study period 2006-2012 of Thyroid disorders (240XX-246XX), HSV-1 (054XX) and VZV (053XX). The unique patients included in the sample will be identified with at least one medical claim for Thyroid disorder, and α-HHV diagnosis during the study period.  Statistical analyses will be done using 2x2 contingency table developed by using  patients with Thyroid disorder only, patients with α-HHV diagnosis only, patients that have both Thyroid disorder plus α-HHV diagnoses, and all patients without Thyroid or α-HHV diagnosis. The abstraction of the data will be done using Microsoft^® Access and the statistical analysis will be done using SAS^®