OBJECTIVES: Estimate direct medical costs of selected acute complications in patients with non-valvular atrial fibrillation (NVAF) at the Social Security (EsSalud) in Peru. METHODS: The electronic database of EsSalud´s reference hospital: Hospital Nacional Guillermo Almenara Irigoyen (HNGAI) was used to identify the study population. International Classification of Diseases (ICD) 10 codes were used to identify patients with NVAF and select complications of AF.  Complications of interest are: ischemic stroke, hemorrhagic stroke, systemic embolism and myocardial infarction.  Stroke events were classified by severity as mild, moderate, severe or fatal. All cases from 2011 -2012 meeting the inclusion criteria were reviewed. Patient level data from clinical charts was extracted to estimate resource utilization per patient per event. Costs were estimated using EsSalud´s 2013 tariffs manual and expressed per patient in 2013 USD. RESULTS: Ischemic stroke costs were estimated at $1,259, $1,818, $ 4,910, and $2,829.19 for mild, moderate, severe and fatal events, respectively. Hemmorhagic stroke were estimated at $1,707, $2,419, $11,991 and $2,111 for mild, moderate, severe and fatal event, respectively. Systemic embolism and myocardial infarction were estimated to cost $1,707 and $1,703 respectively. CONCLUSIONS: For AF patients within EsSalud, hemorrhagic stroke costs are higher than those estimated for ischemic stroke. As expected, costs increase as the severity of the event increase. These cost estimates can be used as patient-level costs inputs for economic model analysis of AF and its complications, from the perspective of EsSalud in Peru.