OBJECTIVES: The objectives of this study were to assess the quality of life and the determinants affecting QoL in children with epilepsy using Pediatric quality of life questionnaire (PedsQL). METHODS: A prospective observational study was conducted at a public hospital. In these study children less than 18 years of age, diagnosed with epilepsy were included. HRQoL was assessed using PedsQL, which comprised of 23 questions related to physical, emotional, social and school functioning. After getting consent, scale was administered to both parents and subjects separately. Multivariate logistic regression was done to assess the potential determinants of low HRQoL scores. RESULTS: A total of 270 children with epilepsy were included in this study. Mean age and mean duration of antiepileptic drug treatment was found to be 11.2 years and 21.6±12 months respectively. Mean total score according to PedsQL was found to be 89.6±6.7 (Psychological subscale score 84.7±1.2, physical subscale score 94.4±5.9, emotional subscale score 85.6±16, social subscale score 94.7±9.9 and school subscale score 73.9±12.5). Long duration of antiepileptic drug treatment treatment, polytherapy, low mean seizure free interval, male gender, presence of ADR and high mean duration of disease are significantly (P <0.05) associated with low HRQoL scores. CONCLUSIONS: Epilepsy has a negative impact on their HRQoL. The determinants found by this study will help in framing different strategies to improve patient’s compliance and their HRQoL.