OBJECTIVES: Obesity is associated with many health-related risk factors and is a significant economic burden on society. The objectives of this study were to examine the prevalence of patient-reported comorbidities, productivity loss and health-related quality of life (HRQoL) across different BMI ranges. METHODS: Overweight/obese patients from the 2012 U.S. National Health and Wellness Survey, a nationally representative, online survey of 71,157 respondents aged ≥18 years, were categorized and analyzed by their BMI: overweight (BMI>=25 & <30 kg/m), obese class I (BMI>=30 & <35 kg/m), obese class II (BMI>=35 & <40 kg/m), and obese class III (BMI>=40 kg/m). Patients provided information on HRQoL (SF-36v2: mental and physical component summary (MCS, PCS) and SF-6D (health utility) scores), productivity loss (Work Productivity and Activity Impairment questionnaire) and comorbidities (sleep-difficulties, insomnia, pain, anxiety and depression) they experienced in the past 12 months. RESULTS: Among 45,641 overweight/obese patients, 49.8% were overweight, 27.9% were obese class I, 12.5% were obese class II, and 9.8% were obese class III. The proportions of patients experiencing sleep-difficulties (overweight: 20.3%; obese class I: 24.6%; obese class II: 28.6%; obese class III: 35.3%), pain (overweight: 32.6%; obese class I: 38.1%; obese class II: 42.5%; obese class III: 48.5%), insomnia, anxiety and depression increased along with BMI increase (all p<0.001). MCS (overweight: 50.0; obese class I: 48.9; obese class II: 47.8; obese class III: 46.1), PCS (overweight: 51.1; obese class I: 48.8; obese class II: 46.5; obese class III: 43.0) and health utility scores declined with an increase in BMI (all p<0.001). Among employed patients, overall work impairment increased as BMI increased (p<0.001). CONCLUSIONS: Data suggests a greater prevalence of pain, depression, anxiety, and sleep problems as BMI increases. Increasing BMI is also associated with significantly worsening HRQoL. Successful obesity prevention and management may help improve patients’ quality of life and productivity.