OBJECTIVES: To investigate the association between anxiety and comorbid obesity and hypertension in US children over a 8-year period using data from the National Health and Nutritional Examination Survey among those with anxiety or hypertension. METHODS: We built a logistic regression model using a sample of 717 respondents aged 0-18 between 2005 and 2012. RESULTS: Out of 717 subjects, 49.2% were female, 50.1% were male, 11.5% were between the ages of 0-5, 37.8% between the ages of 6-10, 26% between the ages of 11-15, 24.5% between the ages of 16-18, 28.7% were White, 71.3% were non-White,16.4% were obese and 3.6% had hypertension. Obesity is a significant predictor of anxiety. Obese children are about 2.1 times more likely (p=0.0002) to suffer from anxiety compared with children who are not obese. A significant association was also found between anxiety and gender (p=0.05; OR=0.341) and family income (p=0.06; OR=1.012). CONCLUSIONS: Obesity predicts the prevalence of anxiety in children. The implication is that maintaining a healthy body mass index (BMI) in children could significantly reduce the prevalence of anxiety in children.