OBJECTIVES: Accordingly to the third Cancer plan, organized screening (OS) of cervical cancer (CC) among women aged 25-65 should be implemented in the forthcoming years in France. The most cost-effective way to implement OS in the French health care system in regard of this objective is yet to be determined. METHODS: A microsimulation model was developed with the French National Institute of Cancer (INCa) in collaboration with an expert board involving clinical experts and stakeholder representatives (French national health insurance, ministry of health, patients and professionals). A closed cohort of women eligible to CC screening and representative in terms of age and participation to individual screening (IS) is modelled on a lifetime horizon. Different OS strategies, additive to the existing IS, determining invitation and recall modalities, screening tests and algorithms and OS periodicity were assessed. RESULTS: OS based on primary HPV-testing every 5 or 10 years are the most efficient strategies. They dominate the actual IS-only situation due to the better sensitivity and specificity of the HPV-test over Pap-test and the longer period between CC screenings. HPV-testing every 3-years leads to major additional costs with little impact on health. The strategy based on primary p16/Ki67 immunohistochemistry allows for the best results but generates important additional costs. Switching confirmation Pap-tests in positive women to p16/Ki67 immunohistochemistry appears to be a more interesting approach, providing better outcomes with little extra costs. OS scenarios based on Pap-test provide intermediate results but come with additional costs. CONCLUSIONS: OS strategies based on HPV-test appear highly efficient although those results rely on the assumption that OS periodicity will be respected. Implementing such OS modalities will require major adaptations to the current CC screening organization. Pap-test based strategies might constitute simpler modalities to set-up OS while preparing the field to secure appropriate implementation of other OS screening modalities.