OBJECTIVES: In a context of budgetary constraints, the need for hospitals to deliver innovative care improving patient outcomes requires to make informed decisions for innovation integration. In France, hospital-based HTA is not widely spread: only few centers undertake formalized assessment and the decision-making criteria are not well defined. This research aimed at determining a set of relevant criteria for decision-makers, to assess their satisfaction and identify potential obstacles in the decision-making process. METHODS:  A multidisciplinary group from 10 university hospitals designed a survey. A list of criteria was extracted from literature and revised after a beta-test with 7 decision-makers, leading to 47 criteria. Between October 2015 and February 2016, an electronic survey was sent to decision-makers asking them to assess the importance of each criterion on a 5-level Likert scale (from “Useless” to “Essential”). The analysis focused on the percentage of the two best ratings (“Important” and “Essential”) for each criterion. Decision-makers satisfaction was collected on a 4-level scale (from “Unsatisfied” to ”Very satisfied”). Limits could be expressed through open response.  RESULTS:  Preliminary results from 42 decision-makers in 24 French hospitals show that 11 criteria were ranked as “Important” or “Essential” by at least 74% (on average 87%) of respondents: clinical benefit, running costs, quality of clinical evidence, budgetary impact, investment costs, safety, appropriate human resources, compliance with strategic lines, efficiency, structural impact and number of patients. At least 36% (on average 51%) of respondents ranked those criteria as “Essential”. Only 20% of decision-makers were very satisfied with the decision-making process in their hospital. Significant obstacles were identified in four domains: innovation management, innovation assessment, decision-making and innovation funding. CONCLUSIONS:  We determined 11 decision-making criteria which gathered large consensus and could be used in each hospital to design a multi-criteria tool aiming at improving decision-making process in French hospitals.