OBJECTIVES: Assess the use of eHIS by HCPs and the perception of its value in reducing medication risks and safety for patients. METHODS: A cross-sectional online survey of HCPs was conducted (FDA cooperative-agreement #5U18FD004653-01) in Nov-Dec 2013 using a U.S HCP panel. A geographically diverse sample of HCPs (Primary Care Physicians (PCPs), Pharmacists, Nurse Practitioners (NPs) and Physician Assistants (PAs)) spending >=50% of time in direct ambulatory patient care (PCP/PA/NP) or working in a retail pharmacy (Pharmacists), with >=2 yrs of practice experience and seeing/consulting >=20 pts/wk were recruited. Survey collected beliefs about medication risks, information seeking behavior and communication on medication risk/safety. RESULTS: Eight hundred HCPs (200 each of PCPs/NPs/PAs/Pharmacists) participated. Approximately two-thirds reported using eHIS for >50% of their patients in respective clinical practices/pharmacies. HCPs reported following computerized/eHIS capabilities in their settings: record patient history/demographic information (87%), record clinical notes (incl. patient’s medications/allergies) (86%), order medications (82%), view/order lab tests (75%), eHIS ability provide warnings of drug interaction/contraindications (to prescribers) (66%), share patient information electronically with other prescribers/providers (53%), provide patients with clinical summaries for each visit (52%), provide reminders for guideline-based interventions or screening tests (46%), provide patients with alerts if medications they take receives an FDA safety alert or recall (35%), allow patients to access their medical records or information on medications they are taking, incl. risk/safety information (34%), and exchange secure messages with patients (31%). These responses varied by HCP-type. Eighty-two percent of HCPs agreed their eHIS adds value to their practice by reducing medication risks/safety for patients. CONCLUSIONS: eHIS was widely used and was reported to provide value in reducing medication risks/safety. However, eHIS use to provide medication alerts regarding medicine risk/safety or provide patients access to medical records or information on medication risks/safety was reported by only one-third of study participants.