OBJECTIVES:  Multiple Sclerosis (MS) is a chronic disease associated with substantial clinical and socioeconomic burden. MS patients experience increasing levels of disability as their disease progresses. This study investigates the association between increasing Expanded Disability Status Scale (EDSS) and its impact on relapsing-remitting (RRMS) MS patients. METHODS: RRMS patients in Brazil were drawn from the Adelphi MS Disease Specific Programme, a global cross-sectional study of MS patients. Multiple logistic, linear and ordered logistic regressions determined the association between physician reported EDSS (<3, 3-5 and >5) and presence of an informal caregiver, weekly informal caregiver hours, and employment status. Regressions adjusted for age, gender, BMI and number of concomitant conditions. Reference category was <3. RESULTS: