OBJECTIVES:  Pseudomonas aeruginosa is one of the most common pathogens responsible for nosocomial infections. Multidrug resistant isolates of P. aeruginosa pose significant health risks to hospitalized patients. Carbapenems are prescribed as the last resort antibiotics against the multidrug resistant isolates. The aim of this study was to assess the susceptibility pattern of clinical isolates of P. aeruginosa to carbapenems, and to obtain baseline information for empirical therapy. METHODS:  One hundred and twenty two multidrug resistant P. aeruginosa isolates were collected from indoor patients in the Khyber Teaching Hospital (KTH) in Peshawar, Pakistan during January to June 2016. Kirby-bauer disc diffusion tests were used to check susceptibility of the isolates to carbapenem antibiotics (imipenem, meropenem, doripenem). RESULTS:  Twenty three percent of the isolates (n=28) were found resistant, with varying resistance level to the tested carbapenems such as imipenem (23%), meropenem (15%) and doripenem (11%). CONCLUSIONS:  This study confirms that resistance is emerging in P. aeruginosa isolates to carbapenems- the last resort antibiotics. Prevalence of such a high resistance to carbapenems is very alarming and urgently requires implementation of infection control measures in order to prevent the spread of carbapenem resistance among bacterial communities. Resistance is potentially linked to the injudicious use of antibiotics. A strict antibiotics treatment policy is required to preserve antibiotics and protect humans from the drug-resistant deadly infectious diseases.