OBJECTIVES:  Technology assessment provides information to policy makers in order to inform decisions about the adoption and diffusion of health care technology. This study aims to develop recommendations for good practice of health technology assessment (HTA) in the Egyptian Ministry of health to ensure transparency, accountability and efficiency. METHODS: A focus group of decision makers that included experts in health economics, healthcare policy, pricing and reimbursement systems in Egypt was established. The focus group has reviewed the principles of good practice of HTA available on ISPOR web site , the Egyptian laws and the World Health Organization guidelines on good governance in medecine . Focus group meetings were held to develop core recommendations before preparing a draft report. The recommendations were developed by using the Quasi-Delphi method. RESULTS: Revisiting the Egyptian guidelines for economic evaluations reporting, establishing a clear system for setting priorities for HTA and engaging all key stakeholders to consider a wide range of evidence were the core recommendations for setting a good practice for HTA in Egypt. HTA should be an unbiased and transparent exercise and its findings need to be communicated appropriately to different decision makers. Addressing issues of generalizability and transferability should also be considered when undertaking HTA in Egypt. CONCLUSIONS: Effective pharmaceutical pricing and reimbursement systems, based on HTA, are essential for allocation of our limited resources that can lead to efficient sustainable health care system. The focus group defines and gains a consensus on a set of recommendations adopting good HTA practice that provides a support of a transparent and uniform process in the evaluation of clinical benefits and costs of pharmaceuticals. These recommendations will enhance access to clinically effective and cost-effective care, improve the efficiency of care and achieve better health for the Egyptian population.