OBJECTIVES: The aim of this study is to describe the application of Decision-oriented HTA method to assess the femtosecond laser-assisted cataract surgery (FLACS) compared to conventional cataract surgery (CCS). METHODS:  This study reviews the spectrum of evidence regarding the feasibility, safety, technical and organizational features, costs and economic factors of FLACS compared to CCS, by using doHTA methodology. The information is summarized in a hierarchical decision tree by means of Key Performance Indicators (KPI), subsequently weighted through pairwise comparisons. For each pair of elements in the pairwise comparison, a verbal judgment by professionals involved in the assessment was gathered, and then converted in the numerical ratings. Lastly, FLACS and CCS were ranked against lowest indicators of decision tree. A global score was determined delivering a consequent ranking between the alternatives. RESULTS: According to the professionals judgments, “safety” along with “clinical effectiveness” make up almost 60% of the whole evaluation, while the weights associated to “costs and economic evaluation” dimension was 14.63%, followed by “technical characteristics of technology” (14.28%) and “organizational aspects” (10.51%) domains. FLACS seems to overcome CCS with several important developments such as increased precision of anterior capsulotomy, reduced ultrasound power requirement during phacoemulsification, decreased collateral tissue damage. Notwithstanding such clinical improvements, FLACS is more expensive than its comparator; the relative costs were also analyzed in the cost-minimization analysis. CONCLUSIONS:  The Hospital’s Top Management has decided to consider the doHTA evaluation as a whole. Indeed, although FLACS had the highest capital investment cost, its safety, clinical and technical features led to its high score. Moreover, due to the peculiar features of doHTA (i.e. the quantitative integration of different aspects of the assessment and their synthetic representation), the Top Management has provided a timely response between both alternatives: the implementation of FLACS seems to be attainable.