O OBJECTIVES: In many countries, economic evaluations require using a societal perspective. There is, however, a lack of evidence on the societal costs of advanced melanoma. We investigated informal care, work status, paid and unpaid work, and productivity losses in Dutch advanced cutaneous melanoma patients. METHODS: We included all advanced cutaneous melanoma patients participating in the Dutch Melanoma Treatment Registry (DMTR) who completed the resource use questionnaire for melanoma (RUQ-M). We assessed informal care in hours of care received in the last four weeks. Similarly, paid and unpaid work and productivity losses were assessed in hours and days in the last four weeks. RESULTS: A total of 145 patients (median age: 63 years; male: 60%) completed the RUQ-M questionnaire between November 2014 and April 2016. Halve of the patients (50%) received on average 50.9 hours of informal care. Informal care was provided, on average, as i) 29 hours of assistance with household activities to 79% of patients, ii) 33 hours of personal care to 26% of patients, and iii) 26.1 hours of practical support to 73% of patients. Regarding work status, 41% was either employed or self-employed, 37% was retired, 10% was houseman/ housewife, and 3% was jobless. Employed and self-employed patients worked on average 29.3 hours per week; most of them worked 3 (19%), 4 (21%) or 5 (47%) days per week. Regarding productivity losses, 6% of patients was unable to work due to illness (sickness-benefit). Of the patients who were able to work, 77% was on average 12 days absent of work due to illness. Moreover, 22% of patients suffered physical and/ or psychological problems at work during 8.6 days. Furthermore, 29% of patients performed 9.5 less days of unpaid work. CONCLUSIONS: Informal care and productivity losses are important in advanced cutaneous melanoma, and are, therefore, relevant societal costs in economic evaluations.