OBJECTIVES: Zoster is a frequent disease which incidence, severity and impact increase with age. A study was designed to investigate the risk of Herpes Zoster (HZ) in Chronic Obstructive Pulmonary Disease (COPD) patients and its related health care resources consumption. METHODS:  From the population based registries of Valencia Region, Spain, a cohort of all HZ patients aged over 49 years was followed up from 2009-2014. HZ and COPD were defined using ICD-9 codes and severe cases considered when there was inhaled corticosteroids prescription (COPD-ICS). We compared incidence of HZ among groups [non-COPD, COPD and COPD-ICS populations] and health care resource consumption due to HZ in the 6 months following HZ diagnosis through different statistical generalized linear models. RESULTS: The cohort consisted of 2,289,485 subjects ≥ 50 years old, including 161,317 COPD patients of which 28,565 were COPD-ICS. HZ incidence rates were 1105 cases/100,000//year in COPD population and 1300 cases/100,000/year in severe COPD patients. As in general population, incidence increases with age in all subgroups. The risk of HZ increased by 39% among COPD patients and by 61% among COPD-ICS with respect to non-COPD. COPD patients had increased severity of disease as demonstrated through more healthcare resource used: 5% more outpatient visits due to HZ than non-COPD (RR 1.053, 95% CI: 1.031-1.076), higher medication rates (RR 1.227, 95% CI: 1.168-1.289), especially for severe COPD patients (RR 1.461, 95% CI: 1.334-1.599), both zoster severity and healthcare resources used increase with age (from 8% outpatients visits for aged 60-69 to 19% for 70-79 with respect to 50-59 and 26% medication rates for aged 60-69 to 58% for 70-79).  CONCLUSIONS: Beyond age, having underlying conditions and especially COPD, increase the risk, severity and impact of zoster episodes in senior population. It confirms the significant public health interest of enlarging access to vaccination in Spain.