DESCRIPTION:  The increasing attention on assessing the value of oncology products has resulted in close scrutiny of the validity of health economic models evaluating the cost-effectiveness of new interventions. The field of oncology outcomes research is complicated by the diversity of diseases within oncology, the rapidly changing nature of treatments, and the complexities of measuring cost and quality of life/patient reported outcomes. The Oncology Health Economic Modeling Working Group structured a systematic literature review to focus on contemporary and existing health economic modeling methods in advanced oncology and the availability of data on health utility, disease management, treatment patterns, resource use and costs in the post-progression/post-response period. This forum will present the literature review, the search criteria and challenges from the point of view of multiple stakeholders. The audience will be invited to comment and provide feedback on the project. The presentation may be of interest to health economists, modelers, outcomes researchers and anyone involved in health technology assessment of oncology therapies.