OBJECTIVES:  No adherence to asthma guidelines poses a significant barrier to optimal disease management and control. Our aim was to evaluate the effectiveness of information and administrative assistance provided to help patient adherence to asthma guidelines in Greece. METHODS:  The study sample consisted of 32 males and 68 females (mean age =48.1years, SD=18) visiting the Emergency Department (ED) of a public respiratory hospital with severe asthma attacks. Patients were equally divided in: intervention and control group. Administrative assistance to schedule a follow-up visit after 30 days was provided to the intervention group while patients of the control group were not provided this type of assistance RESULTS:  In total, 61 patients complied with the follow-up consultation; 41 patients from the intervention group and 20 patients from the control group (p<0.001). Adherent patients were those for whom a follow up was scheduled compared with those with no scheduled follow-up visit (odds ratio-OR=8.22). Moreover, patients with insurance coverage (n=88) were more compliant than uninsured (n=12) ones (OR=14.63) Patients with uncontrolled/severe asthma, as classified according to asthma hospitalization days in the previous year, experienced frequent attacks and visited the ED more often (OR=271.47). No adherence to medication regimens (due to lack of prescription or relevant medical advice) posed a significant barrier to asthma control; medication non-adherent patients were more likely to visit the ED more than once (OR=3.52), compared with medication adherent patients CONCLUSIONS: Proper asthma treatment/control requires adherence to current management guidelines. Monitoring, close tracking, and regular evaluation of asthma patients via effective administrative procedures and scheduled appointments for follow-up, is a strategy that can be utilized to lead to improved asthma control. Potential savings in hospitalization costs linked to ineffective control of asthma is crucial and could be achieved by the systematic and effective out-patient management of the disease.