OBJECTIVES:  Diabetes Mellitus is a large and growing condition in the EU5, prevalence ranges from 4.8% in Italy to 8.9% in Germany. The total direct cost of diabetes in the EU5 was €90 Billion (2010). The management of diabetes is a growing concern given the already high prevalence and associated high costs. As we seek to improve the management of diabetes, it’s important to integrate patient preferences into policy and market access decisions. METHODS: The 2014 EU Roper Diabetes Study was conducted among 3,013 diagnosed adult diabetes patients across the EU5. During 50-min telephone interviews, respondents were asked about their willingness to investigate new techniques and preferences for managing their diabetes. Data were compared across countries, diabetes type, age group, year since diagnosis and current therapy to determine relative openness to new techniques. Statistical significance testing between analytic groups was performed at the 95% confidence level. RESULTS:  In total 46.9% of diabetes patients reported that they would “like to investigate or try new techniques for managing [their] diabetes”. Italian diabetes patients were significantly more likely to “strongly” or “somewhat” agree (62.2%) with this statement compared to the remaining EU5 countries. German diabetes patients (52.6%) were significantly more likely to agree compared to Spain (42.4%) and the UK (42.2%). Across Europe, patient’s openness to trying new techniques was significantly associated with insulin use, younger ages, and whether they had self-tested in the last month. Italian respondents were also significantly more likely to ask their doctor specific questions about managing their diabetes and less likely to prefer their clinician manage their diabetes for them. CONCLUSIONS:  Given that much of the onus of care for diabetes is reliant on patient compliance, the perspective of the patient must be taken into account as we (manufacturers, governments, HTA bodies) search for innovative solutions for the management of diabetes.