OBJECTIVES: Hypertention is a common non-communicable diseases in both male and female populations, 1 out of every 3 adults have high blood pressure. Reseaches in treatment cost of hypertension in Vietnam were limited. Therefore, the aim of this study was evaluate the treatment cost of patients with hypertension. METHODS: A cross-sectional study was conducted with database of all patients hospitalized for hypertension at Tran Van Thoi hospital within 2014 and 2015. Patients who did not finish the treatment course in research hospital or died within treatment were eliminated from this study. The medical direct cost was evaluated in this study. RESULTS: Data from 1939 patients with nearly 70% female, 72.1% over 60 years old; in 85.7% with health insurance, 26% patiens with cardiovascular diseases and 72% having other disease except hypertension was analysed. With average hospital stay length of 6 days, the average total cost per patient was 755.48±12.55 thousand VND, including 76% covered by health insurance and 24% covered by patients. In the stucture of total cost, cost for preclinical tests, medications and hospital beds were 312,8±2,1; 202,6 ± 9,2 and 148,1±1,9 thousand VND, respectively. The influencing factors on the total treatment cost include gender (p=0.001); occupation (p=0.008). The total treatment cost of male was higher than those of female (827.7 and 723.7 thousand VND, p=0.001). There was a statistical significant difference between total treatment cost of farmers and retired patients (680.8; 782.2 thousand VND and p = 0.009). CONCLUSIONS: The total treatment cost was 755.48±12.55 thousand VND with majority part for preclinical test. The main factors affecting the total cost of hypertention inpatients include gender, occupation.