OBJECTIVES: Nowadays, new medical technologies and related new possibilities for improving the healthcare in all areas are constantly appearing. Premature uterine activity remains one of the most important signals of preterm labor that needs to be monitored. The aim of this study is to compare the prenatal care supported by telemonitoring with the currently used practice in obstetrics and gynaecology consulting rooms. METHODS: Clinical outcomes have been obtained through a literature review of clinical trials. Value engineering methods and multiple-criteria decision making methods were used, especially Saaty’s matrix and the Concordance Discordance Analysis method, for setting the scales of criteria and effects, respectively. Costs are processed by a systematic cost analysis. Cost-effectiveness analysis compares the standard prenatal treatment with the telemonitoring system from payer’s perspective. RESULTS: A total of 44 patients have been enrolled in the study. The total costs are CZK 182 934 (~EUR 6 758) for the standard ambulatory prenatal care of pregnants at a high risk of preterm labor, and CZK 200 485 (~EUR 7 406) for the prenatal care with interventions through the preterm uterine activity telemonitoring system. The CEA indicator value is 7.27 for the standard care, and 14.71 for the telemonitoring care, while the ICER is CZK 10 834 (~EUR 400). CONCLUSIONS: Total costs are higher in the group with telemonitoring care, but cost-effectiveness analysis showed that the use of telemonitoring in the prenatal care is significantly more cost effective than the standard care, which is now practiced in most gynaecology-obstetrics departments in the Czech Republic.