OBJECTIVES:  To estimate the social costs and health losses associated to female breast cancer (BC) in Portugal in 2014. METHODS:  The impact on population health was measured using Disability Adjusted Life Years (DALYs). Years Lost due to Disability (YLD) were estimated applying an incidence perspective model originally introduced by Kruijshaar and Barendreght (2004). Disability weights from the European Disability Weights Project were used. Data from the Portuguese Regional Cancer Registries were used to estimate incidence rates. The Years of Life Lost (YLL) due to BC premature mortality were computed using mortality data reported by the National Statistics Institute weighted by the standard life expectancy at age of death. The analysis included direct costs (inpatients and outpatients costs) as well as indirect costs associated to productivity loss. Costs estimation was based on the NHS hospitals’ Diagnosis Related Group database, national legislation, data from IMS Health, national reports on breast cancer screening and NHS expenditure with medicinal products as well as opinions from an experts’ panel. RESULTS:  A total of 1,664 deaths in Portugal in 2014 were caused by BC, about 3.2% of the overall female deaths in Portugal. The YLL caused by BC in 2014 summed 13,425 representing 6.2% of YLL in the female population of the country. For 2014 the YLD estimated were 9,667. The total disease burden attributable to female BC is thus estimated at 23,092 DALY. The direct cost attributed to BC was €146.1 million, about 1.4% of all Portuguese health expenditures. The indirect costs added up to €163.3 million, reflecting the relative youth of women with BC. The economic burden of BC is substantial, totaling € 309 million, about 0.18% of Portuguese GDP. CONCLUSIONS: BC is an important cause of disease burden and costs in Portugal and deserves adequate attention from policy makers.