OBJECTIVES:  Comorbidity-based health-related quality of life (HRQoL) scores from primary health care setting (PHCS) are needed frequently in the initiation of cost-utility simulation modelling. Yet, PHCS HRQoL studies and scores are rare – general population-based or specialist care setting HRQoL scores are more frequently available. We study PHCS HRQoL comorbidity-based. We also estimate the baseline potential to benefit (PTB) and 3-months unmet medical need (UMN) by applying a matched-adjusted indirect comparison (MAIC), which was developed by us to predict the multivariate matched general population control (MGPC) HRQoL scores at individual level. METHODS:  Unselected PHCS patients (N 519) filled EQ-5D-3L questionnaire (British preferences) during Effective Health Centre Study in three Finnish health centres located in Pirkanmaa. 0.07 was considered to be the minimum clinically important difference (MID). Stata MP 14.1 was used. RESULTS:  0.74 and 0.78 mean baseline and three month EQ-5D-3L scores were observed, respectively. The lowest (0.54, 0.54 or 0.63) mean baseline scores were observed for patients with neck, back or neurologic comorbidity, respectively. Patients with diabetes, hypertension or coronary heart disease had the highest respective (0.75, 0.74 or 0.74) mean baseline scores. Patients with no, 1, 2, 3, 4 and 5 or more comorbidities had 0.82 (0.91), 0.75 (0.86), 0.74 (0.76), 0.73 (0.75), 0.69 (0.67) and 0.50 (0.53) scores at the baseline (three months), respectively. The highest and lowest PTB at baseline was estimated for patients with one and four comorbidities, respectively. Patients with 5 or more comorbidities and no comorbidity had the highest and lowest UMN at three months, respectively. MID UMN was observed for heart failure, asthma, neurologic disease or inflammatory bowel disease patients. CONCLUSIONS: PHCS HRQoL scores are needed. The UMN seems to increase as the function of comorbidity. Yet, the PTB decreases as the function of comorbidity. Patients presenting with some spesific comorbidities had potentially persistent residual disutility.