OBJECTIVES: related to increasing incidence of colorectal cancer, treatment cost data helps to evaluate the burden to the health care system and enhances to establish effective public health intervention programme (eg screening). The objective was to calculate colorectal cancer treatment costs in Estonia. METHODS: anonymous hospitalized (into North Estonia Medical Centre) colorectal cancer patients’ data and prescriptions’ costs, were obtained from Estonian Health Insurance Fund for years 2011-2013. The hospitalized patients had ICD C18 to C21 in their treatment record first time in 2011 and cost for the first treatment year was calculated. In order to obtain cost data by the cancer stage, expert opinion was used and cancer stages (I, II-III and IV) were distinguished. The average treatment cost based on treatment invoices and prescription medicines cost was calculated. Data analysis was performed using software Stata 11. RESULTS:  the sample of 329 patients (age range 40-95) had altogether 2873 treatment invoices. Cancer stage cost per patient were: I stage 5,990, II-III stage 10,383 and for IV stage 6,135 EUR. The II and III stages were not separated because no specific treatment or procedure was found to be set as criteria. The sum of first year’s treatment was altogether 2,179,053 EUR, which made 85,7% of all the 2011-2013 costs. CONCLUSIONS:  Cost calculations indicate that most of costs are formed during the first treatment year. Cancer treatment cost data can be used to evaluate cost-effectiveness of national screening programme. Colorectal cancer screening programmes are in place in many countries in Europe, and screening programme will be established in Estonia soon. The possible limitation of the study might be, that data from one hospital only was used, however this is the biggest hospital from the 2 higher level hospitals, which treat colorectal cancer patients. Therefore, it covers majority of colorectal cancer patients cost in Estonia.