OBJECTIVES: Legislation was implemented in Ireland to allow pharmacists to partake in the Seasonal Influenza Vaccination Programme at a national level. The aim of this research is to evaluate the impact of introducing a pharmacist-led vaccination campaign on the Irish healthcare system. The clinical and economic benefit obtained by a cohort of patients who obtained an influenza vaccination in a pharmacy setting will be estimated. METHODS: Data was collected from patients who availed of an influenza vaccination service offered by a community pharmacy chain at multiple locations in the Republic of Ireland during the 2013/14 influenza season. Demographic information from sample data was applied to national population levels. A method described by Preaud et al.was adapted to estimate the clinical and economic benefit gained from vaccination of patients by a community pharmacist in Ireland in 2013/14. RESULTS: Pharmacist vaccination services averted a total of 848 influenza cases across all age groups during the 2013/2014 influenza season. Due to receipt of vaccination in a pharmacy setting, 444 influenza-related GP visits were prevented. In terms of more serious influenza-associated events, 11 hospitalisations and five influenza-related deaths were averted. Costs averted were approximately €305,000. These were principally wider societal-related costs associated with lost productivity CONCLUSIONS: The number of influenza-related events averted due to vaccination in a pharmacy setting is a welcome benefit to the Irish healthcare system, especially in winter months where services are already overburdened.