OBJECTIVES:  Out of Hospital Cardiac Arrest (OOHCA) is a leading cause of death worldwide and accounts for more than 50% of all cardiovascular deaths. The evidence-based intervention of mild hypothermia induction, improves survival and both short- and long-term neurological outcomes. The objective of this analysis was to estimate the annual budget impact of the introduction of a computerized Temperature Management System (TMS) with water circulating hydrogel coated pads in the management of comatose post-cardiac arrest patients with return of spontaneous circulation from a Greek hospital perspective. METHODS:  A budget impact model originally developed for the UK was customized locally in order to evaluate the economic impact of the device. Model inputs were elicited from the literature, cooling device companies, hospitals tender data and a clinical expert. Different scenarios were developed, considering the costs and market shares of the existing hypothermia techniques in Greece. The main outcome measures were total costs and cost per patient of each hypothermia implementation technique and total incremental budget impact. A one-way sensitivity analysis was also performed to gauge the robustness of the results and identify influential variables. RESULTS:  The analysis demonstrates that economic benefits may be observed through the incorporation of this cooling device in therapeutic hypothermia treatment. The annual cost savings for managing 100 patients were estimated at 5.242€. Under base case assumptions, an increased uptake of this cooling device showed accumulated savings of 29.483€ by year 2. The annual total complications costs were much lower by using this advanced TMS option in comparison to other cooling methods. These cost savings were found to be robust across a range of scenarios. CONCLUSIONS:  In addition to clinical benefits, the use of this advanced, automated, non-invasive TMS could be economically beneficial and lead to savings.