OBJECTIVES: To assess the knowledge, attitude and practice (KAP) of Pharmacist regarding adverse drug reaction (ADRs) and pharmacovigilance in public hospitals Quetta. METHODS:  A cross sectional and questionnaire- based study design was used among the professional pharmacists in seven public hospitals of Quetta city, who were performing their duties in hospital as pharmacist and chief pharmacist. A total of 26 questionnaires were present in survey comprised of (knowledge 7, Attitude 10, practice 9) for the assessment of pharmacists (KAP). A total of 140 questionnaires were distributed to the pharmacists. The completion of the questionnaire by pharmacist was taken as their consent to participate in the study. 127 pharmacists filled and returned the questionnaires at given time. RESULTS: The results of knowledge, attitude and practice about pharmacovigilance and ADR reporting system were very promising. Based on majority of respondents were male dominated (n= 89(70.1%). Majority of participants (n= 68 (53.5%) having age ranges between 24 – 34 years and experience group (n= 62(50%) between 4-7 years. having Current position (n= 123(96.9%) were hospital pharmacist. Overall knowledge score of all the responding professional pharmacists (127), about two thirds 85 (69.9%) of the respondents had poor knowledge on the pharmacovigilance and ADR reporting system, while 41 (31.1%) had adequate knowledge about it. Among the 127 professionals, 103 (81.1%) had positive attitude, while 24 (18.9%) had negative attitude regarding pharmacovigilance and ADR reporting system. Moreover, majority of the respondents 102 (80.3%) had poor practice and 25(19.7%) of respondents had good knowledge about it. CONCLUSIONS: The pharmacist working in different hospitals of Quetta has poor knowledge, negative attitude and poor practice towards pharmacovigilance and ADR reporting. Establishment of pharmacovigilance Centre in facility and availability of ADR reporting form is necessary.