A SYSTEMATIC REVIEW OF TREATMENT PATTERNS IN PATIENTS WITH RECURRENT GLIOBLASTOMA IN THE REAL WORLD
Author(s)
Davies J, Reyes-Rivera I
F. Hoffmann-La Roche AG, Basel, Switzerland
Presentation Documents
OBJECTIVES: Despite aggressive front-line treatment, most patients with glioblastoma multiforme (GBM) develop recurrent disease 5–8 months after diagnosis. Systemic treatment at recurrence can provide clinically meaningful benefits for patients. A systematic literature review was carried out to describe the treatment patterns of patients with recurrent GBM (rGBM) in routine clinical practice. METHODS: This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A tiered search string that included a combination of keywords and medical subject headings (MeSH) was used to search for English language studies in the following databases: BIOSIS Previews, Current Contents Connect®, Embase®, Gale Group PROMT®, International Pharmaceutical Abstracts, Medline, and SciSearch (January 1 2005–December 31 2015). RESULTS: The search yielded 350 citations with two additional citations identified through examination of reference lists of the included publications. After applying the selection criteria, six articles that described eight different study cohorts were included in the qualitative data synthesis. Seven study cohorts were retrospective analyses and one was a physician panel survey. Six study cohorts included patients from Europe, and two included patients from the USA CONCLUSIONS: The studies in this qualitative systematic review demonstrate that few treatment options are available for rGBM patients. In Europe, where bevacizumab is not approved for rGBM, the treatment paradigm varies between countries and several options are used (including regimens without bevacizumab). In the USA, where bevacizumab is indicated for rGBM, bevacizumab-containing regimens have become the standard of care.
Conference/Value in Health Info
2016-10, ISPOR Europe 2016, Vienna, Austria
Value in Health, Vol. 19, No. 7 (November 2016)
Code
PCN312
Topic
Health Service Delivery & Process of Care
Topic Subcategory
Treatment Patterns and Guidelines
Disease
Oncology