OBJECTIVES: In addition to warfarin, the drugs dabigatran and rivaroxaban have been used to prevent strokes in patients with atrial fibrillation. However, their impact on patients’ health-related quality of life remains unknown. This study aimed to use the visual analogue scale (VAS) and standard gamble (SG) to elicit patient-reported utilities for health states related to stroke and stroke prophylaxis by the three anticoagulants. METHODS: A cross-sectional survey was administered in 2012 to a convenience sample of 100 patients taking warfarin in an anticoagulation clinic. The survey questionnaire included socio-demographics, clinical characteristics, and questions to elicit utilities for seven chronic and four temporary health states. Participants completed the questionnaire in English or Chinese, depending on their preference. Logical consistency and correlations between the VAS and SG were assessed. RESULTS: When the SG was used, the three health states with the highest mean utilities were “well on rivaroxaban” (0.90), “current health state” (0.86) and “well on warfarin” (0.86). The three health states with the lowest mean utilities were intracranial bleeding (ICH) (-0.09), major ischemic stroke (IS) (-0.01) and myocardial infarction (0.45). Logical consistency was found: 1) the mean utilities of “well on warfarin”, “well on dabigatran”, “well on rivaroxaban” and “current health state” were higher than those of other chronic health states (all p <0.001); 2) the mean utilities of major IS and ICH were lower than those of minor IS and transient ischemic attack (all p <0.001); and 3) the mean utility of major extracranial hemorrhage (ECH) was lower than that of minor ECH (all p <0.001). Significant correlations were found between the two measures (all p <0.05). CONCLUSIONS: The elicited utilities of the anticoagulants were, in a decreasing order: rivaroxaban, warfarin and dabigatran. The results of this study can be used in future cost-utility analysis.