OBJECTIVES:   In Canada, approximately 25% of all births are delivered via cesarean section and this rate continues to rise. C-sections are associated with up to 20 times the surgical site infection (SSI) incidence rate as compared to vaginal births. A recent Canadian prospective trial assessing SSI in women after c-section found the incidence rate to be 7%.  This study was conducted to determine the budget impact of incorporating the use of 2-Octyl cyanoacrylate in Canadian hospitals as an anti-microbial topical skin adhesive after c-section. METHODS: Clinical and economic data was obtained from peer-reviewed literature and through case-costing data from a large Canadian hospital. The efficacy data used to demonstrate a reduction in SSIs from the use of 2-Octyl cyanoacrylate was obtained through a large retrospective trial.  One and two way sensitivity analyses were conducted on economic and clinical parameters to ensure robustness. RESULTS: Incorporating 2-Octyl cyanoacrylate use as an anti-microbial tissue sealant after c-section has been found to reduce the incidence of SSI from 7.0% to 3.01%.  Based on model calculations a hospital that completes a total of 500 c-sections per year would see 35 of its patients develop a SSI using standard preventative strategies. By incorporating the use of 2-Octyl cyanoacrylate into the standard of care the same hospital would see approximately 15 SSIs in the same patient population, for a total reduction of 20 SSIs. Treatment costs for SSI vary greatly dependent on whether the infection is superficial or deep/organ space. Taking this into account, the model establishes that the use of 2-Octyl cyanoacrylate has the potential to provide a yearly net cost savings of $232, 660.00 when compared to the use of standard wound closure products.  CONCLUSIONS: 2-Octyl cyanoacrylate is an anti-microbial tissue sealant that can be used cost-effectively post c-section in Canadian hospitals.