OBJECTIVES: Smoking is one of the major risk factors in chronic obstructive pulmonary disease (COPD) patients, with 90% of deaths from COPD being attributable to smoking. According to the Centers for Disease Control and Prevention (CDC), smoking cessation reduces the risk of developing COPD. Still, little is known about the use of smoking cessation agents and the factors that affect their use among patients. The purpose of the study is to identify the socio-demographic factors that affect the use of these agents among COPD patients. METHODS: A retrospective study was done to identify smokers having COPD (ICD9:490-496) and those who use smoking cessation agents from 2006-2010 using Medical Expenditure Panel Survey (MEPS) data. A multiple logistic regression model was built to identify significant socio- demographic predictors associated with the use of smoking cessation agents. RESULTS: Out of 2218 smokers with COPD, 176 reported use of smoking cessation agents during the 5 year period. Logistic regression showed African Americans were less likely to use smoking cessation agents than Caucasians (OR =0.379, 95% CI 0.208-0.688), patients having public insurance were more likely to report use of these agents than other insurances (OR = 2.619, 95% CI 1.265- 5.422), and patients with higher educational levels (OR=1.127, 95% CI 1.043- 1.217) were more likely to use these agents. CONCLUSIONS: Results showed that a large number of patients continued to smoke even after the diagnosis of COPD whereas; only 176 patients (8%) used smoking cessation agents. Race, educational level, and insurance status were significant predictors of smoking cessation agents’ use. Further research needs to be done to evaluate reasons for minimal use of these agents in COPD patients. Results showed inconsistent use of these agents among different population groups; hence there is a requirement for need based smoking cessation programs.