OBJECTIVES: A retrospective analysis was conducted to compare the prevalence and incidence of acute urinary tract infections (UTIs) and genital infections (GIs) between adults with type 2 diabetes mellitus (T2DM) versus those without DM (no-DM). METHODS: Commercially-insured adults were selected from a large, US claims database from 2006-2010. Patients with T2DM were identified via diagnosis codes and use of non-insulin, anti-diabetic medications. Prevalence and incidence of UTIs (cystitis, urethritis, or acute pyelonephritis) or GIs (females: vulvovaginal candidiasis and bacterial vaginosis; males: balanitis) were estimated by gender for each calendar year (CY), and averages over CYs were reported.  Prevalence was defined as the proportion of individuals with 1+ medical claim for UTI or GI, and incidence as the number of events over 1000 person-years, assuming each event lasted ≤ 30 days. Age-adjusted prevalence ratio (PR) and incidence rate ratio (IRR) between T2DM vs. no-DM were reported with 95% confidence intervals (CIs). RESULTS: 18-30 million individuals with T2DM were identified per CY; 6.8% (2006) to 8.8% (2010). Prevalence and incidence of UTI among T2DM males were 4.6% and 55.3/1000 person-years and were higher among T2DM males than no-DM (PR [95% CI]: 2.23[2.22-2.24]; IRR [95% CI]: 2.36[2.35-2.37]). The prevalence and incidence of GIs among T2DM males were 0.4% and 4.3/1000 person-years and were higher among T2DM males than no-DM (PR: 3.99[3.92-4.05]; IRR: 4.00[3.92-4.07]). Prevalence and incidence of UTI among T2DM females were 14.1% and 180.5/1000 person-years, and rates of GI were 4.2% and 46.4/1000 person-years. The prevalence and incidence of UTIs were higher among T2DM females than no-DM (PR: 1.77[1.77-1.78]; IRR: 1.88[1.87-1.88]). The prevalence and incidence of GIs were higher among T2DM females than no-DM (PR: 1.40[1.40-1.41]; IRR: 1.39[1.38-1.39]). CONCLUSIONS: T2DM was positively associated with acute urogenital conditions for both males and females.