OBJECTIVES: Wet Age-related Macular Degeneration (wAMD) is one of the major causes of visual impairment in Japan. However the patient burden from wAMD has not been widely reported. The objective of this study was to characterize how Japanese wAMD patients are affected by the disease. METHODS: This is a multi-site observational study across Japan on wAMD patients who have received medical treatment during the past 12 months. Collected patient-reported outcome measures included Quality of Life using the National Eye Institute Visual Functioning Questionnaire-25 (NEI-VFQ-25) and depression scale by the Geriatric Depression Scale-Short Version-Japanese (GDS-S-J). Patients also reported on treatment satisfaction, caregiver assistance, and wAMD-associated comorbidities. RESULTS: Interim data for 211 patients are reported here; 97.2% of patients were 60 years of age and over.  The mean score of NEI-VFQ-25 was 68.19±17.84 and General Vision (45.78±18.07) was the lowest among 12 sub-domains; 11.4% of patients had a score of 6 or above in GDS-S-J, indicating mild depression. A total of 38.4% and 45.5% of patients were dissatisfied with their treatment in terms on vision improvement and the time it takes for the treatment to work, respectively. A total of 10.4% of patients needed assistance with their daily tasks, but of those, only 4.7% had a caregiver to help them day-to-day. 1.9% used paid services at home with the average of 1.3±0.47 hours per week; half of these patients used yearlong service and the rest used 6 months only; 5.9% of patients visited other doctors because of a fall which was related to their vision impairment.    CONCLUSIONS: Our analyses showed that 38-45% of patients were dissatisfied with their current treatment. Very few patients who required assistance were able to have a caregiver to help them day-to-day. Paid services were also barely utilized.