OBJECTIVES: To determinate the impact of a managed care program for multiple sclerosis (MS) patients in Colombia through changes in health-related quality of life (HRQoL). METHODS: Seeking to improve the quality of life of MS patients treated with interferon beta 1b it was established a two-mode (basic or full) patients support program at each stage of illness. To estimate the program impact it was used the econometric differences method comparing the HRQoL measures from a treatment group defined as the patients in the full mode program with those from a control group defined as the patients in the basic mode program. The dependent variable was SF6D measures, and the independent variables were each mode of the support program, sex and three levels of disability (mild, moderate and severe) were control variables. The SF6D utility measures were obtained by converting SF36 results from 360 patients (a sample calculated to be statistically significant at country level), evaluated since January 2010 to April 2010 using the Quality Metric Health Outcomes® software 4.0.  RESULTS: The HRQoL of patients was 0.669 (0.301-1). At average a male (0.689) patient has better HRQoL measure than the woman (0.660) patient. The linear regression showed that patients in the full mode would have HRQoL measures of 0.781, 0.723 and 0.648 for mild, moderate and severe disability respectively, compared with 0.742, 0.644 and 0.657 in the basic mode respectively. The differences in HRQoL between full and basic modes were 0.039 (P<0.05) in the mild disability, 0.079 (P<0.05) in the moderate disability and there were not found significant difference in patients with severe disability   CONCLUSIONS: The support program does impact positively on the HRQoL in MS patients with a mild or moderate disability for the Colombian context. These results suggest that best outcomes come from early entry at this support program.