OBJECTIVES: The study evaluated the impact of a health educational intervention in improvement of health related quality of life (HRQoL) in Pakistani Hepatitis-B patients.  METHODS: A non-clinical randomized control trial was conducted. Hepatitis B patients received an educational intervention through hospital pharmacists who provided them with information about Hepatitis-B treatment and management and improvement of HRQoL. Health Related Quality of Life was measured by Euroqol (EQ-5D). Descriptive statistics were used to describe the demographic characteristics of the patients. Inferential statistics (Chi square test, Mann-Whitney U test) were used for inter-group comparison. The intra- group comparison was performed by Wilcoxon Rank Sum test. SPSS 17.0 was used for data analysis. RESULTS: Three hundred and ninety Hepatitis-B patients were randomly assigned to the study [195 in each group i.e. control group (CG) and the intervention group (IG)]. No significant differences were observed in either group for mean age, gender, education, occupation, income and locality. There was significant (p<0.001) increase in EQ-5D score from 0.3498±0.3178 to 0.4739±0.2624 (in post interventional intervention group). The results revealed non-statistical significant (p=0.563) between the Interventional group (0.4726±0.2522) and control group (0.4745±0.2791) among overall HRQoL scores.  CONCLUSIONS: The pharmacist-focused intervention led to a significant increase in the patient’s health related quality of life. Therefore, the role of pharmacists in patient education must be formalized and acknowledged as an official part of the health care system.